Pro-Collagen Multi-Peptide Booster harnesses newly researched peptide technology to target key proteins in skin's extracellular matrix to support collagen and elastin production. These signal proteins direct skin-beneficial substances to the optimal areas of skin to address signs of aging including crow’s feet, wrinkles & loss of firmness in four weeks.

Cutting-edge repairing pro-collagen peptides take cues from substances found in skin’s deeper dermal-epidermal junction to support and visibly improve facial architecture. Hydrating hyaluronic acid and strengthening amino acids further firm, plump + smooth skin in as little as 15 minutes.

Apply once or twice daily to face, eye area and neck after cleansing, toning and exfoliating. Dispense a pearl-sized amount alone or add to your favorite serum or non-SPF moisturizer. For daytime, follow with SPF 30+.


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Pharmaceutical Development and Technology, January 2022, pages 108–125
Health Science Reports, June 2021, pages 1–7
Frontiers in Chemistry, October 2020, pages
International Journal of Molecular Sciences, December 2019, pages 1–12
Life Sciences, October 2018, pages 22–33
Cosmetics, March 2018, pages 1–9

Key Ingredients
Tridecapeptide-1⁠, Palmitoyl Tetrapeptide-72 Amide⁠, Sh-Polypeptide-121⁠, SYN-TC⁠, Polyglucuronic Acid⁠, Glyceryl Glucoside⁠

All Ingredients
Water⁠, Glycerin⁠, Pentylene Glycol⁠, Hydrolyzed Yeast Extract⁠, Pyrus Malus (Apple) Fruit Extract⁠, Dimethicone⁠, Propanediol⁠, 1, 2-Hexanediol⁠, Glyceryl Glucoside⁠, Palmitoyl Tetrapeptide-72 Amide⁠, Sh-Polypeptide-121⁠, SYN-TC⁠, Tridecapeptide-1⁠, Polyglucuronic Acid⁠, Sodium Hyaluronate⁠, C9-12 Alkane⁠, Ammonium Polyacryloyldimethyl Taurate⁠, Polygonum Bistorta Root Extract⁠, Bacillus Ferment⁠, Lecithin⁠, Sodium Phytate⁠, Coco Caprylate/Caprate⁠, Hexylene Glycol⁠, Cetyl Hydroxyethylcellulose⁠, Xanthan Gum⁠, Ethylhexylglycerin⁠, Caprylyl Glycol⁠, Magnesium Chloride⁠, Potassium Sorbate⁠, Sodium Benzoate⁠

What are peptides?

Peptides are short chains of amino acids that act as building blocks of proteins including collagen, elastin and keratin. Each peptide plays a key role in skin’s texture and strength.

How does the Pro-Collagen Multi-Peptide Booster work?

In their natural form, peptides can be unstable, so we opted for highly stabilized lab-engineered peptides in our Pro-Collagen Multi-Peptide Booster. These 'synthetic' peptides can penetrate the upper layers of skin and 'activate' areas that help visibly improve tone, hydration, a feeling of suppleness and a smoother surface. Did you know? Synthetic peptides are created as exact copies of protein fragments in skin. They’re more stable on and within skin, remain intact on skin longer and better reach their target areas.

What is the difference between the new Pro-Collagen Multi-Peptide Booster and the original Peptide Booster?

While the original Peptide Booster was a great formula with wonderful benefits, the Pro-Collagen Multi-Peptide Booster features newer, highly specialized peptides that have a more targeted impact on loss of firmness, decreased resilience, wrinkles and skin's foundational architecture for even better results. Both formulas share a similar lightweight gel texture.

How does Pro-Collagen Multi-Peptide Booster work to visually improve lines and wrinkles in just 15 minutes?

A particularly innovative peptide in this formula, tridecapeptide-1, works by interrupting a key step within skin that leads to the formation of expression lines. With this process sidestepped, facial lines and wrinkles begin to smooth out, and skin looks younger and less fatigued.  

Does the Pro-Collagen Multi-Peptide Booster replace my other anti-aging ingredients or products?

No. This focused formula complements your other anti-aging products by reinforcing and restructuring the surface layers of skin with highly specialized peptides that affect the dermal-epidermal junction. This unique, targeted benefit is something ingredients such as vitamin C, niacinamide and retinol just cannot do; however, each of those ingredients have their own benefits and can be used alongside peptides.

Can I use the Pro-Collagen Multi-Peptide Booster if I have sensitive or rosacea-prone skin?

It’s not a problem to use the Pro-Collagen Multi-Peptide Booster if you have sensitive or rosacea-prone skin. In fact, its fragrance-free formula contains potent skin-soothing and skin-replenishing antioxidants that help calm.

How long will it take to see an improvement in my skin when using the Pro-Collagen Multi-Peptide Booster?

When using the Pro-Collagen Multi-Peptide Booster, you will notice smoother expression lines and wrinkles within 15 minutes with results lasting up to 4 hours. After 4 weeks of consistent use, you will notice a reduction of depth and volume in the appearance of fine lines and wrinkles.

When should I use the Pro-Collagen Multi-Peptide Booster in my skin care routine?

You can apply the Pro-Collagen Multi-Peptide Booster up to twice per day. After cleansing, toning and exfoliating, apply the rest of your serums, treatments and boosters in order from thinnest to thickest texture. Finish with moisturizer as your last step for PM and moisturizer with SPF during the daytime

What is the difference between the Pro-Collagen Multi-Peptide Booster and similar products on the market?

The Pro-Collagen Multi-Peptide Booster includes a blend of distinctive peptides that are not only used at clinically efficacious levels but are combined with key supporting ingredients that revive healthy cellular energy and influence key collagens and other proteins needed to rebuild and preserve youthful skin. Like all Paula’s Choice products, this booster is also free from natural and synthetic fragrance and other irritants, plus it’s packaged stably to preserve ingredient integrity and efficacy. This product takes a top-down signaling approach to restore and maintain skin's structural support system. While some competitor products may contain more peptides in terms of ingredient count, they are likely using levels below the recommended standard (especially if the product's price is below $40).