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Symphytum Officinale Extract

Rating: Worst
Categories: Plant Extracts

Symphytum Officinale Extract at a Glance

  • Plant extract with some potential skin benefits
  • Contains pyrrolizidine alkaloids, associated with health risks
  • Safety profile remains uncertain due to limited research
  • Best to avoid when it comes to personal care products

Symphytum Officinale Extract Description

_Symphytum officinale_ extract (also known as comfrey extract) is an herb-derived ingredient touted in research for its antioxidant and soothing properties. However, this ingredient has earned a controversial reputation in skin care due to the presence of pyrrolizidine alkaloids (PAs).

PAs are a group of secondary metabolites in plants associated with potential health risks. Although the risks are primarily associated with oral ingestion, concerns have arisen for topical applications as well. Regulatory agencies worldwide have varying stances on the safety of comfrey in personal care products, with governing bodies in some countries imposing dosage/usage restrictions.

While animal studies have explored potential side effects, larger human trials are needed to definitively assess toxicity. Further complicating matters, research has revealed mixed findings on the safety of _Symphytum officinale_ extract and the lack of standardization for its cosmetic use adds to the uncertainty. At the time of this writing, the independent Cosmetic Ingredient Review Expert Panel has not assessed the safety of _Symphytum officinale_ extract.

Given the abundance of proven, safe, soothing, antioxidant-rich natural ingredients available for use in skin care formulas, there’s no reason to gamble with this.
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Symphytum Officinale Extract References

International Journal of Molecular Science, March 2024, pages 1-22
International Journal of Molecular Science, December 2023, pages 1-29
Drugs and Drugs and Lactation Database, May 2021, pages 1–2
Molecules, April 2021, pages 1-13
Industrial Crops and Products, September 2023, ePublication
Natural Product Research, May 2017, pages 605-609
Phytotherapy, April 2015, pages 1,117-1,122
Zeitschrift für Gerontologie und Geriatrie, April 2014, pages 228–235